Genetically Modified Microorganisms in Cell and Gene Therapy With the growth of gene and cell therapies, advances in the development and validation of suitable in vivo and in vitro assays have become necessary in order to test the efficacy, safety, and ultimately the potency of these products. We’re experienced in genetically modified microorganisms, which are essential in this area. GMMs are used to produce medicines and vaccines that treat or prevent diseases.
Here are some applications:
Genetically modified bacteria were the first organisms to be modified in the laboratory due to their simple genetics, and are particularly important in producing large amounts of pure human proteins for use in medicine. Genetically modified viruses can be used to deliver genes that can cure diseases in humans.
In addition, our transgenic mouse models provide researchers with high-quality, validated research models for gene research and drug development.
Vaccine Challenge Studies
The rise in emerging diseases, bioterrorism, resistance to existing antimicrobials, and the apparent increase in virulence of some viruses has spurred the drive to develop new prophylactic vaccines. Vaccine challenge studies involve the deliberate infection of a healthy host and allow for:
A greater understanding of the infecting pathogen in terms of identifying both the cellular and systemic targets of the infective Estimating the potency/efficacy of either the prophylactic or therapeutic treatment product Many ethical and safety considerations need to be addressed for vaccine challenge studies, and assessment is dependent on the pathogen in terms of biosafety level, virulence, route of administration, and host species.
Pharmacology is the science dealing with biochemical and physiologic aspects of drug effects, including absorption, distribution, metabolism, elimination, toxicity doses, and specific mechanisms of drug action.
